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Evidence for postmeiotic effect of t factors causing segregation distortion in mouse

Nature volume 253, pages 137–138 (1975)Cite this article

Abstract

THE t complex of the mouse consists of a large series of genetic factors often characterised by embryonic lethality of the homozygotes, reduced male fertility of viable homozygotes, suppression of recombination over a relatively long chromosomal segment and relatively frequent occurrence in natural mouse populations. Most t factors also possess a component which interacts with the Brachyury (T) gene and causes complete absence of the tail in T/t heterozygotes. One of the most fascinating but least explored characteristics of the t factors is their effect on genetic segregation. A male mouse carrying a t factor in a heterozygous condition (t/−) often transmits the factor to almost 100% of its progeny, in defiance of the Mendelian principle requiring 1:1 segregation.

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References

  1. Sandier, L., and Novitski, E., Am. Nat., 41, 105–110 (1957).

    Article  Google Scholar 

  2. Klein, J., Proc. natn. Acad. Sci. U.S.A., 68, 1594–1597 (1971).

    Article  ADS  CAS  Google Scholar 

  3. Ford, C. E., and Hamerton, J. L., Stain Technol., 31, 247–251 (1956).

    Article  CAS  Google Scholar 

  4. Meredith, R., Chromosoma, 26, 254–258 (1969).

    Article  CAS  Google Scholar 

  5. Braden, A. W. H., Nature, 181, 786–787 (1958).

    Article  ADS  CAS  Google Scholar 

  6. Yanagisawa, K., Dunn, L. C., and Bennett, D., Genetics, 46, 1635–1644 (1961).

    CAS  PubMed  PubMed Central  Google Scholar 

  7. Erickson, R. P., Nature new Biol., 243, 210–212 (1973).

    Article  CAS  Google Scholar 

  8. Yanagisawa, K., Pollard, D. R., Bennett, D., Dunn, L. C., and Boyse, E. A., Immunogenetics, 1, 91–96 (1974).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Human Genetics, The University of Michigan School of Medicine, Ann Arbor, Michigan, 48104

    CRAIG HAMMERBERG

  2. Department of Microbiology, The University of Texas, Southwestern Medical School, Dallas, Texas, 75235

    JAN KLEIN

Authors
  1. CRAIG HAMMERBERG
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  2. JAN KLEIN
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HAMMERBERG, C., KLEIN, J. Evidence for postmeiotic effect of t factors causing segregation distortion in mouse. Nature 253, 137–138 (1975). https://doi.org/10.1038/253137a0

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  • DOI: https://doi.org/10.1038/253137a0

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