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Induction of dominant lethal mutation in male mice by ethyl alcohol

Abstract

THERE have been many studies of the effects of ethyl alcohol on reproductive performance and of the genetic aspects of this relationship1–10. But in spite of extensive investigations of the genetic determination of alcohol preference in experimental animals, there has been little research on other genetic aspects of alcohol consumption11–13. It has been assumed for a long time that alcohol presents no genetic hazard. Using the dominant lethal technique, we have now found that in mice ethyl alcohol can be mutagenic when given under certain conditions.

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References

  1. Bluhum, A., S.B. preuss Akad. Wiss., 35, 549 (1921).

    Google Scholar 

  2. Bluhum, A., Arch. Russen-Ges. Biol., 16, 1 (1924).

    Google Scholar 

  3. Bluhum, A., Biol. Zbl., 50, 102 (1930).

    Google Scholar 

  4. MacDowell, E. C., Genetics, 7, 117 (1922).

    CAS  PubMed  PubMed Central  Google Scholar 

  5. MacDowell, E. C., Proc. Soc. exp. Biol. N.Y., 21, 480 (1924).

    Article  Google Scholar 

  6. MacDowell, E. C., Lord, E. M., and MacDowell, C. G., Proc. Soc. exp. Biol. N.Y., 23, 652 (1926).

    Article  Google Scholar 

  7. MacDowell, E. C., and Lord, E. M., Arch. Entw. Mech. Org., 109, 549 (1927).

    Article  CAS  Google Scholar 

  8. MacDowell, E. C., and Lord, E. M., Arch. Entw. Mech. Org., 110, 427 (1927).

    Article  CAS  Google Scholar 

  9. MacDowell, E. C., Am. Naturalist, 62, 48 (1928).

    Article  Google Scholar 

  10. Hanson, F. B., Sholes, F. N., and Heys, F., Genetics, 13, 121 (1928).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Miron, L., Q. Jl Stud. Alcohol, 13, 365 (1952).

    Google Scholar 

  12. Aschkenasy-Lelu, C. r. hebd. Séanc. Acad. Sci., 246, 1275 (1958); (Abstr. Q. Jl Stud. Alcohol., 22, 660 (1961)).

    CAS  Google Scholar 

  13. Blignaut, F. W., Commun. Univ. S. Africa, Series C No. 55, 18 (1965); (Abstr. Q. Jl Stud. Alcohol., 28, 155 (1967)).

    Google Scholar 

  14. Stockard, C. R., Proc. Am. phil. Soc., 62, 311 (1923).

    Google Scholar 

  15. Ehling, U. H., Cumming, R. B., and Malling, H. V., Mutation Res., 5, 417 (1968).

    Article  CAS  Google Scholar 

  16. Russell, W. L., Russell, L. B., and Kimball, A. W., Am. Naturalist, 88, 269 (1956).

    Article  Google Scholar 

  17. Bateman, A. J., Heredity, 12, 213 (1958).

    Article  Google Scholar 

  18. Lyon, M. F., Phillips, R. J. S., and Searle, A. G., Genet. Res. Camb., 5, 448 (1964).

    Article  Google Scholar 

  19. Hanson, F. B., Anat. Rec., 26, 532 (1923).

    Google Scholar 

  20. Auerbech, C., Science, 110, 419 (1949).

    Article  ADS  Google Scholar 

  21. Alderson, T., Nature, 207, 164 (1965).

    Article  ADS  CAS  Google Scholar 

  22. Jensen, K. A., Kirk, I., Kolmark, G., and Westergaard, W., Cold Spring Harb. Symp. quant. Biol., 16, 245 (1951).

    Article  CAS  Google Scholar 

  23. Demerec, M., Bertani, G., and Flint, J., Am. Naturalist, 85, 119 (1951).

    Article  CAS  Google Scholar 

  24. Jones, K. L., Smith, D. W., Ulleland, C. N., and Streissguth, A. P., Lancet, i, 1267 (1973).

    Article  Google Scholar 

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BADR, F., BADR, R. Induction of dominant lethal mutation in male mice by ethyl alcohol. Nature 253, 134–136 (1975). https://doi.org/10.1038/253134a0

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