Abstract
HERPESVIRUSES are the most important candidates for human cancer agents. The Epstein–Barr virus (EBV) in particular is suspected of being the causal agent in Burkitt's lymphoma and nasopharyngeal carcinoma1. Immunological principles, well understood from vaccine prophylaxis of viral diseases, provide the potential for the eventual control of herpesvirus-induced neoplasia. The development of safe and efficient cancer vaccines with the human candidate herpesviruses is, however, difficult, as there are no reliable in vitro or experimental animal methods for detecting oncogenic potential in preparations which might be applicable to the human subject. We are studying the problems of herpesvirus cancer vaccines in non-human primates. Two members of the herpesvirus family, H. saimiri (HVS) and H. ateles (HVA), induce malignant lymphoma and leukemia in several New World monkey species2,3. HVS-induced lymphoma in cotton topped (CT) marmoset monkeys (Saguinus oedipus) has been used in this study as all monkeys inoculated with HVS regularly develop malignant lymphoma within two months4,5. This investigation describes the effect of a killed herpesvirus cancer vaccine in protecting non-human primates against malignant lymphoma.
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LAUFS, R., STEINKE, H. Vaccination of non-human primates against malignant lymphoma. Nature 253, 71–72 (1975). https://doi.org/10.1038/253071a0
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DOI: https://doi.org/10.1038/253071a0
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