Abstract
FACTOR VIII-related antigen is present in normal human blood plasma and with conventional separation procedures it is detected in the same fractions as Factor VIII, the active blood clotting factor. Its structure and absolute concentration in plasma are unknown but it is believed to be a protein of high molecular weight. Patients with von Willebrand's disease have antigen levels and Factor VIII levels reduced in approximately the same proportions while haemophiliacs have reduced amounts of Factor VIII but normal concentrations of antigen. A differential diagnosis between these two bleeding diatheses can therefore be made by measuring antigen level. It has been suggested that the reduced amounts of Factor VIII-related antigen in von Willebrand's patients may be responsible for some aspects of the bleeding encountered with this disease and also for some of the platelet abnormalities which are found.
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AUSTEN, D., CAREY, M. & HOWARD, M. Dissociation of Factor VIII-related antigen into subunits. Nature 253, 55–56 (1975). https://doi.org/10.1038/253055a0
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DOI: https://doi.org/10.1038/253055a0
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