Abstract
IN many animal species, relatively low doses of morphine produce not only analgesia but also a state of behavioural excitation, restlessness and increased locomotor activity which has been defined as ‘running fit’1. A large intra-specific variability in locomotor activity has been recorded after the same dose of opiates2 and clear strain differences have also been reported. Morphine for example, has been shown to enhance the locomotor activity of C57BL/6J mice and to drastically reduce it in the DBA/2J strain3.
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OLIVERIO, A., CASTELLANO, C. Experience modifies morphine-induced behavioural excitation of mice. Nature 252, 229–230 (1974). https://doi.org/10.1038/252229a0
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DOI: https://doi.org/10.1038/252229a0
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