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Multiple divergent copies of endogenous C-type virogenes in mammalian cells

Nature volume 252, pages 170–173 (1974)Cite this article

Abstract

IT is characteristic of endogenous C-type viruses that all individual animals of a species (as well as all tissues of each animal) contain, in the chromosomal DNA, nucleic acid sequences that can code for the production of complete C-type viral particles. It is postulated that these sequences (C-type virogenes) are transmitted from parent to progeny with the other cellular genes1. Nucleic acid hybridisation, using either single-stranded or double-stranded 3H-DNA transcripts or labelled 70S RNA as viral probes, has revealed C-type viral nucleic acid sequences in DNA from uninfected tissues of avian2–5, murine6,7, porcine8, feline9–12 and Old World monkey species13.

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Authors and Affiliations

  1. Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland, 20014

    RAOUL E. BENVENISTE & GEORGE J. TODARO

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  1. RAOUL E. BENVENISTE
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  2. GEORGE J. TODARO
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BENVENISTE, R., TODARO, G. Multiple divergent copies of endogenous C-type virogenes in mammalian cells. Nature 252, 170–173 (1974). https://doi.org/10.1038/252170a0

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