Abstract
THE epidermal growth factor (EGF) is a peptide hormone which has been isolated from the submaxillary glands of male mice1,2. It enhances proliferation and keratinisation of embryonic and neonatal epidermis in vivo and in vitro3,4. In spite of these morphologically well documented effects, attempts to demonstrate stimulation of epidermal DNA synthesis have failed5. In this communication we report that EGF considerably enhances precursor incorporation into DNA of chick embryo epidermal explants and that the responsiveness of the tissue to the hormone is increased by foetal calf serum.
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BERTSCH, S., MARKS, F. Effect of foetal calf serum and epidermal growth factor on DNA synthesis in explants of chick embryo epidermis. Nature 251, 517–519 (1974). https://doi.org/10.1038/251517a0
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DOI: https://doi.org/10.1038/251517a0
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