Abstract
THE association of hepatitis B antigen (Australia antigen, HBS Ag) in human serum with DNA polymerase activity was first reported by Hirschman et al.1. This has been confirmed and extended by Kaplan et al.2 who found DNA polymerase activity in preparations of concentrated human hepatitis B antigen which were rich in Dane particles. The DNA polymerase activity previously described by Hirschman et al., however, was considered to be dependent on an RNA template, whereas the DNA polymerase reported by Kaplan et al. appeared to be a DNA-dependent DNA polymerase.
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References
Hirschman, S., Vernace, S., and Schaffner, F., Lancet, i, 1099 (1971).
Kaplan, P., Greenman, R., Gerin, J., Purcell, R., and Robinson, W., J. Virol., 12, 995 (1973).
Maynard, J., Berquist, K., Krushak, D., and Purcell, R., Nature, 237, 514 (1972).
Ling, C., and Overby, L., J. Immun., 109, 834 (1972).
Robinson, W., and Robinson, H., Virology, 44, 457 (1971).
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BRADLEY, D., MAYNARD, J., BERQUIST, K. et al. Hepatitis B and serum DNA polymerase activities in chimpanzees. Nature 251, 356–357 (1974). https://doi.org/10.1038/251356a0
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DOI: https://doi.org/10.1038/251356a0
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