Abstract
USING sequential labelling techniques, I have found that newly synthesised as well as preformed lipids are incorporated into the membrane of the maturing influenza virus, thus contradicting suggestions that only pre-existing phospholipids1–3 are utilised for the synthesis of enveloped viruses. This is not surprising in the light of reports that a selection mechanism exists for fatty acyl chains4,5 (in ortho- and para-myxoviruses) and that many phospholipids6 and neutral lipids7 turn over rapidly in cultured animal cells.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kates, M., Allison, A. C., Tyrrell, D. A. J., and James, A. T., Biochim. biophys. Acta., 52, 455 (1961).
Pfefferkorn, E. R., and Hunter, H. S., Virology, 20, 466 (1963).
Klenk, H.-D., and Choppin, P. W., Virology, 38, 255 (1969).
Blough, H. A., and Lawson, D. E. M., Virology, 36, 286 (1968).
Tiffany, J. M., and Blough, H. A., Science, 163, 573 (1969).
Gallaher, W. R., Weinstein, D. B., and Blough, H. A., Biochem. biophys. Res. Commun., 52, 1252 (1973).
Blough, H. A., Ninth Int. Cong. Biochemistry Stockholm, 407 (1973).
Blough, H. A., and Tiffany, J. M., Adv. Lipid Res., 11, 267 (1973).
Laine, R., Kettunen, M. L., Gahmberg, C. B., Kääriänen, L., and Renkonen, O., J. Virol., 10, 433 (1972).
Quigley, S. P., Rifkin, D. B., and Reich, E., Virology, 50, 550 (1972).
Blough, H. A., and Weinstein, D. B., in Biology of the fibroblast, S. Jusélius Foundation Symp. (edit. by Kulonen, E., and Pikkarainen, J.), 303 (Academic Press, London, 1973).
Blough, H. A., and Merlie, J. P., Virology, 40, 685 (1971).
von Haberer, J., Atomwirtschaft, 10, 36 (1965).
Ben Porat, T., and Kaplan, A. S., Nature, 235, 165 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
BLOUGH, H. Newly synthesised lipids incorporated into influenza virus membranes. Nature 251, 333–335 (1974). https://doi.org/10.1038/251333a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/251333a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
