Abstract
WE recently reported that in (C57BL6/Rij × A/HeJ) F1 (=B6AF1) mice, in which cellular immunity was temporarily suppressed by anti-lymphocyte serum, established B10.D2 skin allografts were hyperacutely rejected after the administration of specific alloantibody and rabbit complement1. From this it was concluded that mouse skin allografts are sensitive to the cytotoxic action of alloantibody in vivo provided an effective species of complement is present at the same time.
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References
Koene, R. A. P., Gerlag, P. G. G., Hagemann, J. F. H. M., van Haelst, U. J. G., and Wijdeveld, P. G. A. B., J. Immun., 111, 520–526 (1973).
De Sousa, M. A. B., Parrott, D. M. V., and Pantelouris, E. M., Clin. exp. Immun., 4, 637–644 (1969).
Manning, D. D., Reed, N. D., and Shaffer, C. F., J. exp. Med., 138, 488–494 (1973).
Billingham, R. E., and Medawar, P. B., J. exp. Biol., 28, 385–402 (1951).
Snell, G. D., J. natn. Cancer Inst., 21, 843–877 (1958).
Koene, R. A. P., and McKenzie, I. F. C., J. Immun., 111, 1894–1901 (1973).
Pantelouris, E. M., Immunology, 20, 247–252 (1971).
Wortis, H. H., Clin. exp. Immun., 8, 305–317 (1971).
Winn, H. J., Ciba Foundation Symposium on Complement, 133–154 (Churchill, London, 1965).
Rosenberg, L. T., and Tachibana, D. K., J. Immun., 89, 861–867 (1962).
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KOENE, R., GERLAG, P., JANSEN, J. et al. Rejection of skin grafts in the nude mouse. Nature 251, 69–70 (1974). https://doi.org/10.1038/251069a0
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DOI: https://doi.org/10.1038/251069a0
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