Abstract
ANTIBODY production to thymus-dependent antigens requires cooperation between thymus derived (T) and bone marrow derived (B) lymphocytes1. B cells are the precursors of the antibody producing cells, but they apparently require the stimulatory influence of T cells in order to be triggered to proliferate and differentiate into plasma cells. The nature of the cooperative stimulus which passes from T cell to B cell is not yet established, though several possibilities have been discussed1–3. There is evidence that T cells produce various mediators which may stimulate B cells, including nonspecific as well as antigen-specific T cell products.
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TAUSSIG, M., MUNRO, A. Removal of specific cooperative T cell factor by anti-H-2 but not by anti-Ig sera. Nature 251, 63–65 (1974). https://doi.org/10.1038/251063a0
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DOI: https://doi.org/10.1038/251063a0
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