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Anatomy of an identified serotonin neurone studied by means of injection of tritiated ‘transmitter’

Abstract

THERE is an identifiable serotonin-containing neurone in each cerebral ganglion of the snail Helix pomatia1. Electrophysiological evidence suggests that each neurone sends a process into each cerebro–buccal connective2,3, and that monosynaptic connections are made in each buccal ganglion with other large identifiable neurones3. Because this neuronal system seems to offer a unique opportunity to study the proposed transmitter role of serotonin3,4, it is important to obtain direct information on the localisation and morphology of the presynaptic endings of the serotonin cell. This is not possible with dye5 or metal ion6 injection techniques, which do not seem to mark processes of the serotonin neurone at distances of more than a few millimetres from the neurone perikaryon.

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PENTREATH, V., COTTRELL, G. Anatomy of an identified serotonin neurone studied by means of injection of tritiated ‘transmitter’. Nature 250, 655–658 (1974). https://doi.org/10.1038/250655a0

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