Abstract
INTRACELLULAR recording of cholinergic synapses in the Onchidium oesophageal ganglia revealed one neurone, V-3, in the visceral ganglion in which neither membrane potential nor conductance changes after perfusion with 0.5 mM acetylcholine. Significant depolarisation with increased membrane conductance was caused by 1.3 mM glycine. This response to glycine is opposite to that of the mammalian spinal motoneurone1–3. Neurones examined in the ganglia, except V-3, were not affected by glycine. Here we report the ionic mechanism of glycine depolarisation, and compare the effect of strychnine on glycine depolarisation with its antagonistic action of mammalian glycine inhibition4.
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OOMURA, Y., SAWADA, M., TANIKAWA, T. et al. Depolarisation of Onchidium neurone by glycine. Nature 250, 258–260 (1974). https://doi.org/10.1038/250258a0
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DOI: https://doi.org/10.1038/250258a0
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