Abstract
CHIMAERIC mice can be made by aggregation of zona-free cleavage stage embryos, and these animals have proved useful in analysing various aspects of development and differentiation. Animals of this type are particularly suited to test models which propose that genetic information is transferred between cells, for example during antibody formation. It has been reported that RNA extracted from immunised rabbits can induce cells homozygous for one immunoglobulin allotype to synthesise antibody molecules carrying a foreign allotype characteristic of the animals from which the RNA had been extracted1–3. Although chimaeric mice have been used to search for gene transfer during the normal in vivo response to antigen, these results have not proved conclusive4.
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References
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GARDNER, R., MUNRO, A. Successful construction of chimaeric rabbit. Nature 250, 146–147 (1974). https://doi.org/10.1038/250146a0
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DOI: https://doi.org/10.1038/250146a0
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