Abstract
THE potency of anti-lymphocytic serum (ALS) in prolonging skin allografts has been well investigated. Four different routes of administration are being used: intravenous1, intraperitoneal2, intramuscular3 and subcutaneous4. Every route has its own advantages and disadvantages from the immunological and clinical point of view and these have been discussed elsewhere5,6. Oral application of ALS was never tried because it was assumed that intact proteins like gamma globulins are enzymatically metabolised before they pass through the intestinal wall. But we shall demonstrate, that even oral application of ALS can prolong the survival time of skin allografts.
Similar content being viewed by others
Article PDF
References
Abaza, H. M., Nolan, B., Watt, J. B., and Woodruff, M. F. A., Transplantation, 4, 618 (1966).
Woodruff, M. F. A., and Anderson, N. F., Ann. N.Y. Acad. Sci., 120, 110 (1964).
Starzl, T. E., Marchiero, T. L., Porter, K. A., Ywasaki, Y., and Cerilli, G. J., Surg. Gynec. Obstet., 124, 301 (1967).
Levy, R. H., and Medawar, P. B., Ann. N.Y. Acad. Sci., 129, 164 (1966).
Berenbaum, M. C., Brent, L., and Kilshaw, P. J., Transplantation, 12, 18 (1971).
Dalton, R. G., Touraine, J. L., Anderson, N. F., and Woodruff, M. F. A., Nature, 225, 1140 (1970).
Brambell, F. W. R., Lancet, ii, 7473 (1966).
Wilson, T. H., and Wiseman, G., J. Physiol., 123 a, 116 (1954).
Thomas, H. C., and Parrot, D. M. V., Immunology (in the press).
Walker, W. A., Isse Bacher, K. J., and Bloch, K. J., Science, 177, 608 (1972).
Moriya, H., Moriwaki, C., and Akimoto, S., Chem. Pharm. Bull., 15, 403 (1967).
Meader, R. D., and Landers, D. F., Am. J. Anat., 121, 763 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SEIFERT, J., RING, J. & BRENDEL, W. Prolongation of skin allografts after oral application of ALS in rats. Nature 249, 776 (1974). https://doi.org/10.1038/249776a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/249776a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.