Abstract
THE present knowledge and theories regarding the fate of synaptic vesicles was reviewed by Holtzman et al.1. Using electron microscopy it has been found that a marker protein (horseradish peroxidase) was incorporated into vesicles of frog neuromuscular junctions by microinvagination of the synaptic plasma membrane2–5 and also into brain synapses6. Heuser and Reese2 have put forward a model postulating recirculation of synaptic vesicle structural materials. Thus, during release of neurotransmitter into the synaptic cleft the vesicle membrane should fuse with the presynaptic membrane, and then vesicles could be reformed by invaginations of the synaptic plasma membrane distant from the synaptic cleft.
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References
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JORGENSEN, O., MELLERUP, E. Endocytotic formation of rat brain synaptic vesicles. Nature 249, 770–771 (1974). https://doi.org/10.1038/249770a0
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DOI: https://doi.org/10.1038/249770a0
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