Abstract
FOUR different DNA polymerases have so far been described in animal cells. Two of them are present in all types of cells1–5: the low molecular weight nuclear DNA polymerase, and the high molecular weight cytoplasmic DNA polymerase. The concentration of only the latter varies during the cell cycle, suggesting its involvement in DNA replication6. The two other DNA polymerases seem to exist only in certain cell types: the first, recently characterised7, seems to be directed by RNA, although differing from the oncornavirus reverse transcriptase8; the second is terminal deoxynucleotidyltransferase which does not exhibit the usual properties of DNA polymerases since it catalyses the polymerisation of deoxyribonucleotides in the absence of template by adding them randomly to the 3′OH end of oligo- or polydeoxyribonucleotides9,10. This last enzyme is tissue-specific: it exists only on the thymus of the different species tested11. Recently the terminal transferase was also identified in blood lymphoblasts of a child suffering from acute lymphoblastic leukaemia12.
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PENIT, C., PARAF, A. & CHAPEVILLE, F. Terminal deoxynucleotidyltransferase in murine plasmocytomas. Nature 249, 755–757 (1974). https://doi.org/10.1038/249755a0
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DOI: https://doi.org/10.1038/249755a0
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