Abstract
ADULT mice injected with murine sarcoma virus Moloney isolate (M-MSV) develop sarcomas which have a high incidence of spontaneous regression. As tumour cells are strongly antigenic and release virus continuously, it is generally agreed that tumour regression is mediated by a host immune reaction1. In fact, M-MSV induces a progressively growing tumour in newborn or adult mice immunologically depressed by X-irradiation, anti-lymphocyte serum or neonatal thymectomy2–4. It is still not clear, however, if humoral or cellular immunity is mainly responsible for M-MSV tumour regression5–8. Both bone marrow-derived (B) and thymusderived (T) lymphocytes have been shown to possess a killer effect in vitro against target cells bearing Moloney virus specified cell surface antigens9,10. Here we report preliminary data which indicate that T lymphocytes are necessary for spontaneous M-MSV tumour regression.
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COLLAVO, D., COLOMBATTI, A., CHIECO-BIANCHI, L. et al. T lymphocyte requirement for MSV tumour prevention or regression. Nature 249, 169–170 (1974). https://doi.org/10.1038/249169a0
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DOI: https://doi.org/10.1038/249169a0
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