Abstract
THE concept of the cell surface mediating specific cell–cell interactions is pertinent to neurogenesis in which the complex cell interactions known to occur may involve the recognition of specific cell surface components. Characterisation of neuronal cell surfaces is necessary to prove this idea and to elucidate functional mechanisms. Antisera raised against lymphoid cells have provided valuable information on the membrane constituents of lymphoid cells1–3, and so I have used a similar approach to identify antigenic components expressed on cells of the nervous system of the mouse. The murine neuroblastoma C1300 can, in culture, give rise to cells which display many of the morphological, biochemical, and physiological properties characteristic of neurones4–9. Here, I present evidence indicating that rat antisera raised against C1300 tumour cells recognise a tissue antigen which is expressed predominantly on mouse brain.
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MARTIN, S. Mouse brain antigen detected by rat anti-C1300 antiserum. Nature 249, 71–73 (1974). https://doi.org/10.1038/249071a0
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DOI: https://doi.org/10.1038/249071a0
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