Abstract
RECEPTORS on the surface at B cells for the fixed C3 component of complement have previously been studied by investigating the adherence to lymphocytes of complement-coated immune complexes and their function interpreted in the light of this reaction1–10. Other nucleated cells, however, notably macrophages, in the secondary lymphoid organs, also have receptors for fixed C3 (refs 3 and 4). It is therefore possible that alexinated complexes might mediate mixed adherence of different cell types which could have more significant functional consequences for complement receptor lymphocytes than just direct binding to their C3 receptors.
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PEPYS, M. Complement-mediated mixed aggregation of murine spleen cells. Nature 249, 51–53 (1974). https://doi.org/10.1038/249051a0
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DOI: https://doi.org/10.1038/249051a0
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