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In vitro suppression of cell mediated autoimmunity in NZB mice

Nature volume 249, pages 43–45 (1974)Cite this article

Abstract

THE spontaneous autoimmune disease of NZB mice is characterised by the development of a variety of autoantibodies, particularly those reacting with autologous erythrocytes as demonstrated by a positive direct Coombs test. The onset of autoantibody production coincides with thymic hyperplasia and is followed by splenomegaly and glomerulonephritis1. All the tissues contain murine leukaemia virus particles (type C) visible on electron microscopy2 and Gross antigen is detectable immunologically3. This virus is vertically transmitted, yet antibodies have been shown to develop to Gross antigen at the time the direct Coomb's test becomes positive4. The role of this virus, if any, in the aetiology of the autoimmune features is still unclear but it has been suggested that this progressive loss of tolerance to Gross antigen is of pathogenetic importance4,5.

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References

  1. Howie, J. B., and Helyer, R. J., Adv. Immun., 9, 215 (1968).

    Article  CAS  PubMed  Google Scholar 

  2. East, J., Prosser, P. R., Holborow, E. J., and Jacquet, H., Lancet, i, 755 (1967).

    Article  CAS  Google Scholar 

  3. Oldstone, M. B. A., Aoki, T., and Dixon, F. J., Science, 174, 843 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Mellors, R. C., Aoki, T., and Huebner, R. J., J. exp. Med., 129, 1045 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Mellors, R. C., Shirai, T., Aoki, T., Huebner, R. J., and Krawczynski, K., J. exp. Med., 133, 113 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Denman, A. M., Russell, A. S., Loewi, G., and Denman, E. J., Clin. exp. Immun., 20, 973 (1971).

    CAS  Google Scholar 

  7. Mellors, R. C., Perspectives in Virology, 6, (edit. by Pollard, M.) 239 (1968).

    Google Scholar 

  8. East, J., and Branca, M., Clin. exp. Immun., 4, 621 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Mellors, R. C., and Chen, Y. H., J. exp. Med., 124, 1031 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. East, T., de Sousa, M. A. B., and Parrot, D. M. V., Transplantation, 3, 711 (1965).

    Article  CAS  PubMed  Google Scholar 

  11. Russell, P. J., Hicks, J. D., Boston, L. E., and Abbot, A., Clin. exp. Immun., 6, 227 (1970).

    CAS  PubMed  PubMed Central  Google Scholar 

  12. Denman, A. M., Russell, A. S., and Denman, E. J., Clin. exp. Immun., 5, 567 (1969).

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Rodney, G. E., Yunis, E. J., and Good, R. A., Clin. exp. Immun., 9, 315 (1971).

    Google Scholar 

  14. Ghaffar, A., Krsiakova, M., and Playfair, J. H. L., Transplantation, 10, 432 (1970).

    Article  CAS  PubMed  Google Scholar 

  15. Waksman, B. H., Raff, M. C., and East, J., Clin. exp. Immun., 11, 1 (1972).

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Stobo, J. D., Talal, N., and Paul, W. E., J. Immun., 109, 692 (1972).

    CAS  PubMed  Google Scholar 

  17. Stutman, O., J. Immun., 109, 602 (1972).

    CAS  PubMed  Google Scholar 

  18. Liburd, E. M., Russell, A. S., and Dossetor, J. B., J. Immun., 111, 1288 (1973).

    CAS  PubMed  Google Scholar 

  19. Stiller, C. R., Russell, A. S., McConnachie, P., Dossetor, J. B., and Diener, E., Clin. exp. Immun., (in the press).

  20. Takasugi, M., and Klein, E., Transplantation, 9, 219 (1970).

    Article  CAS  PubMed  Google Scholar 

  21. Kissmeyer-Niehlsen, F., and Kjerbe, K. E., Histocompatibility testing. 381–83 (Munksgaard, Copenhagen, 1967).

    Google Scholar 

  22. Hellstrom, I., Warner, G. A., Hellstrom, K. E., and Sjogren, H. O., Int. J. Cancer, 11, 280 (1973).

    Article  CAS  PubMed  Google Scholar 

  23. Diener, E., O'Callaghan, F. B., and Kraft, N., J. Immun., 107, 1775 (1971).

    CAS  PubMed  Google Scholar 

  24. Cohen, A., and Schlesinger, M., Transplantation, 10, No. 1, 130 (1970).

    Article  CAS  PubMed  Google Scholar 

  25. Cohen, I. R., Nature new Biol., 242, 60 (1973).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Liburd, E., Russell, A. S., and Dossetor, J. B., Clin. exp. Immun., (in the press).

  27. Phillips, S. M., and Wegman, T. G., J. exp. Med., 137, 291 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Diener, E., Feldmann, M., and Armstrong, W. D., Ann. N.Y. Acad. Sci., 181, 119 (1971).

    Article  ADS  CAS  Google Scholar 

  29. Diener, E., and Feldmann, M., Transplantation Rev., 8, 76 (1972).

    CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Rheumatic Disease Unit, the MRC Transplantation Unit and the Department of Immunology, University of Alberta, Edmonton, Alberta

    ANTHONY S. RUSSELL, EUGENE M. LIBURD & ERWIN DIENER

Authors
  1. ANTHONY S. RUSSELL
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  2. EUGENE M. LIBURD
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  3. ERWIN DIENER
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RUSSELL, A., LIBURD, E. & DIENER, E. In vitro suppression of cell mediated autoimmunity in NZB mice. Nature 249, 43–45 (1974). https://doi.org/10.1038/249043a0

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