Abstract
CERTAIN inbred mice, lethally irradiated and inoculated with bone marrow and spleen cells from F1 hybrids, reject donor-strain skin grafts although they are permanent haemopoietic chimaeras1–3. After rejection their serum is specifically cytotoxic in vitro for donor-strain epidermal cells but not lymphoid cells4, and their leukocytes are stimulated specifically in mixed cultures by donor-strain epidermal cells but not leukocytes5. Thus epidermal cells contain distinctive surface alloantigens (skin-specific or ‘Sk’ alloantigens) which have been suggested to function in vivo as histocompatibility antigens. If this is correct, the rejection of donor-strain skin grafts by persistent chimaeras could be explained as a loss of ‘self-tolerance’ to donor-strain Sk antigens by grafted haemopoietic cells as they proliferate in allogeneic recipients in the absence of these antigens1,2. This interpretation is strengthened because donor-strain skin grafts are not rejected if radiation chimaeras receive donor-strain Sk antigen in the form of epidermal cell suspensions at the time of marrow restoration and thereafter6.
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STEINMULLER, D., LOFGREEN, J. Differential survival of skin and heart allografts in radiation chimaeras provides further evidence for Sk histocompatibility antigen. Nature 248, 796–797 (1974). https://doi.org/10.1038/248796a0
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DOI: https://doi.org/10.1038/248796a0
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