Abstract
AN increase in the serum levels of the α1-acute phase protein, indicative of local tissue damage1 has been shown in rats exposed to cigarette smoke for periods of up to 30 d. The increases correlated well with the degree of damage to the respiratory system as evidenced by the pathological changes observed post mortem in the lungs (L.A.E., T.E.B., D. A. Darcy and J. P. O'Sullivan, unpublished).
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References
Darcy, D. A., Br. J. exp. Path., 45, 281 (1964).
Darcy, D. A., Br. J. exp. Path., 51, 59 (1970).
Darcy, D. A., in Methods in Immunology, and Immunochemistry, III, 200 (edit. by Williams, C. A., and Chase, M. W.) (Academic Press, New York and London, 1971).
Wright, B. M., Lab. Pract., 21, 881 (1972).
Elson, L. G., Betts, T. E., and Passey, R. D., Int. J. Cancer, 9, 666 (1972).
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BETTS, T., ELSON, L. The α1 -acute phase protein response in rats as a possible indicator of the relative smoking risks of different cigarettes. Nature 248, 709–710 (1974). https://doi.org/10.1038/248709a0
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DOI: https://doi.org/10.1038/248709a0
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