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Activation of human T and B lymphocytes by polyclonal mitogens

Nature volume 248, pages 698–701 (1974)Cite this article

Abstract

LYMPHOCYTES can be activated in vitro by a variety of so-called polyclonal stimulants or mitogens (reviewed in refs 1, 2 and 3). These responses characteristically involve a larger proportion of cells than observed with antigen as the eliciting ligand, and the initiating events are widely believed to be independent of any immunogenicity possessed by the stimulant. These features of polyclonal responses provide the rationale for the use of such systems both as a model for the study of activation processes in lymphocytes2 and clinically for the assessment of proliferative potential of blood-borne lymphocytes4.

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Authors and Affiliations

  1. Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College, London

    MELVYN F. GREAVES

  2. Immunology Division, Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex

    GEORGE JANOSSY

  3. Chester Beatty Institute, Royal Cancer Hospital, London

    MICHAEL DOENHOFF

Authors
  1. MELVYN F. GREAVES
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  2. GEORGE JANOSSY
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  3. MICHAEL DOENHOFF
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GREAVES, M., JANOSSY, G. & DOENHOFF, M. Activation of human T and B lymphocytes by polyclonal mitogens. Nature 248, 698–701 (1974). https://doi.org/10.1038/248698a0

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