Abstract
THE replication of the RNA-containing bacteriophages has been found to involve specific replicases, partly coded by the phage genome (reviewed in refs 1 and 2). The replication proceeds by way of a partially double-stranded intermediate form, and the replicases must presumably recognise the 3′-terminal regions of the RNA (+) and (−) strands as start points for copying1,2. There is also evidence that the Qβ replicase recognises a specific internal region of the Qβ RNA molecule, which is involved in forming a replicative complex3. Replication of the smallest animal RNA viruses, the picornaviruses, also requires specific replicases, and has a mechanism4–7 which is not dissimilar to that of the RNA phages, as far as it has been elucidated. We have been studying nucleotide sequences of regions of a picornavirus RNA which might be specifically recognised by its replicase, or have specific roles in the replicative process, in the same way that such sequences have been characterised in the RNA phages1–3.
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PORTER, A., CAREY, N. & FELLNER, P. Presence of a large poly(rC) tract within the RNA of encephalomyocarditis virus. Nature 248, 675–678 (1974). https://doi.org/10.1038/248675a0
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DOI: https://doi.org/10.1038/248675a0
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