Abstract
GENETIC studies of ribosomes in prokaryotes such as Escherichia coli have been facilitated by the use of mutants resistant to antibiotics; mutations which affect either subunit of the ribosome are known1. In eukaryotes, genetic information on the translation apparatus has come mainly from studies of temperature-sensitive mutants2,10, and also cycloheximide resistance, which is known to be a property of the 60S subunit3. Recent studies with resistance to the alkaloid cryptopleurine have shown that Saccharomyces cerevisiae strains resistant to this compound have altered ribosomes4.
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SCHINDLER, D., GRANT, P. & DAVIES, J. Trichodermin resistance—mutation affecting eukaryotic ribosomes. Nature 248, 535–536 (1974). https://doi.org/10.1038/248535a0
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DOI: https://doi.org/10.1038/248535a0
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