Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Control of Cell Division by Very Lysine Rich Histone (F1) Phosphorylation

Abstract

F1 histone phosphorylating activity correlates closely in the cell cycle with the behaviour of the mitotic trigger. It is proposed here that the phosphorylation of F1 histone is the initiation step for mitosis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Delange, R. J., Fambrough, D. M., Smith, E. L., and Bonner, J., J. biol. Chem., 244, 319 (1969).

    CAS  PubMed  Google Scholar 

  2. Bradbury, E. M., Molgaard, H. V., Stephens, R. M., Bolund, L. A., and Johns, E. W., Eur. J. Biochem., 31, 474 (1972).

    Article  CAS  PubMed  Google Scholar 

  3. Bradbury, E. M., Inglis, R. J., Matthews, H. R., and Sarner, N., Eur. J. Biochem., 33, 131 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. Louie, A. J., and Dixon, G. H., Nature new Biol., 243, 164 (1973).

    Article  CAS  PubMed  Google Scholar 

  5. Balhorn, R., Oliver, D., Hohman, P., Chalkley, R., and Granner, D., Biochemistry, N.Y., 11, 3915 (1972).

    Article  CAS  Google Scholar 

  6. Langan, T., Ann. N.Y. Acad. Sci., 185, 166 (1971).

    Article  ADS  CAS  PubMed  Google Scholar 

  7. Mohberg, J., and Rusch, H. P., Arch. Biochem. Biophys., 134, 577 (1969).

    Article  CAS  PubMed  Google Scholar 

  8. Schiltz, E., and Sekeris, C. E., Experientia, 27, 30 (1971).

    Article  CAS  Google Scholar 

  9. Sauer, H., in Microbial Differentiation (edit. by Smith, J. E., and Ashworth, J. M.), 375 (Cambridge University Press, London, 1973).

    Google Scholar 

  10. Lake, R. S., and Salzman, N. P., Biochemistry, N.Y., 11, 4817 (1972).

    Article  CAS  Google Scholar 

  11. Gurley, L. R., Walters, R. A., and Tobey, R. A., Biochem. biophys. Res. Commun., 50, 744 (1973).

    Article  CAS  PubMed  Google Scholar 

  12. Balhorn, R., Balhorn, M., Morris, H. P., and Chalkley, R., Cancer Res., 32, 1775 (1972).

    CAS  PubMed  Google Scholar 

  13. Balhorn, R., Bordwell, J., Sellers, L., Granner, D., and Chalkley, R., Biochem. biophys. Res. Commun., 46, 1326 (1972).

    Article  CAS  PubMed  Google Scholar 

  14. Littau, V. C., Burdick, C. J., Allfrey, V. G., and Mirsky, A. E., Proc. natn. Acad. Sci. U.S.A., 54, 1240 (1965).

    Article  Google Scholar 

  15. Mirsky, A. E., Burdick, C. J., Davidson, E. N., and Littau, V. C., Proc. natn. Acad. Sci. U.S.A., 61, 592 (1968).

    Article  ADS  CAS  Google Scholar 

  16. Chalkley, R., and Jensen, R. H., Biochemistry, N.Y., 7, 4380 (1968).

    Article  CAS  Google Scholar 

  17. Johns, E. W., and Forrester, S., Eur. J. Biochem., 8, 547 (1969).

    Article  CAS  PubMed  Google Scholar 

  18. Panyim, S., Bilek, D., and Chalkley, R., J. biol. Chem., 246, 4206 (1971).

    CAS  PubMed  Google Scholar 

  19. Georgiev, G. P., Il'in, Yu. V., Tikhonenko, S. A., Dobbert, N. N., and Annan'eva, L. N., Mol. Biol., U.S.S.R., 1, 815 (1967).

    CAS  Google Scholar 

  20. Bradbury, E. M., Carpenter, B. G., and Rattle, H. W. E., Nature, 241, 123 (1973).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Dixon, G. H., Louie, A. J., McLeod, A. R., and Sung, M. T., Trans. Biochem. Soc. (in the press).

  22. Lake, R. S., Goidl, J. A., and Salzman, N. P., Expl. Cell Res., 73, 113 (1972).

    Article  CAS  Google Scholar 

  23. Sadgopal, A., and Bonner, J., Biochim. biophys. Acta, 207, 227 (1970).

    Article  CAS  PubMed  Google Scholar 

  24. Lake, R. S., Nature new Biol., 242, 145 (1973).

    Article  CAS  PubMed  Google Scholar 

  25. Stevely, W. S., and Stocken, L. A., Biochem. J., 110, 187 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Sherod, D., Johnson, G., and Chalkley, R., Biochemistry, N.Y., 9, 4611 (1970).

    Article  CAS  PubMed  Google Scholar 

  27. Balhorn, R., Riecke, W. O., and Chalkley, R., Biochemistry, N.Y., 10, 3952 (1971).

    Article  CAS  Google Scholar 

  28. Smith, J. A., and Stocken, L. A., Biochem. J., 131, 859 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Rusch, H. P., Adv. Cell Biol., 1, 297 (1970).

    Article  CAS  Google Scholar 

  30. Oppenheim, A., and Katzir, N., Expl. Cell Res., 68, 224 (1971).

    Article  CAS  Google Scholar 

  31. Carlile, M., and Dee, J., Nature, 215, 832 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  32. Chin, B., Friedrich, P. D., and Bernstein, I. A., J. gen. Microbiol., 71, 93 (1972).

    Article  CAS  PubMed  Google Scholar 

  33. Rusch, H. P., Sachsenmaier, W., Behrens, K., and Gruter, V., J. Cell. Biol., 31, 204 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Sachsenmaier, W., and Rusch, H. P., Expl. Cell Res., 36, 124 (1964).

    Article  CAS  Google Scholar 

  35. Guttes, E., Devi, V. R., and Guttes, S., Experientia, 25, 615 (1969).

    Article  CAS  PubMed  Google Scholar 

  36. Guttes, S., and Guttes, E., J. Cell Biol., 37, 761 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Sachsenmaier, W., Remy, U., and Plattner-Schobel, R., Expl. Cell Res., 73, 41 (1972).

    Article  CAS  Google Scholar 

  38. Brewer, E. N., and Rusch, H. P., Expl. Cell Res., 49, 79 (1968).

    Article  CAS  Google Scholar 

  39. Cummins, J. E., Brewer, E. N., and Rusch, H. P., J. Cell. Biol., 27, 337 (1965).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Cummins, J. E., Blomquist, J., and Rusch, H. P., Science, N.Y., 154, 1343 (1966).

    Article  ADS  CAS  Google Scholar 

  41. Mittermayer, C., Braun, R., and Rusch, H. P., Expl. Cell Res., 38, 33 (1965).

    Article  CAS  Google Scholar 

  42. Daniel, J. W., and Baldwin, H. H., in Methods in Cell Physiology (edit. by Prescott, D. M.), 9 (Academic Press, New York, 1964).

    Google Scholar 

  43. Mohberg, J., and Rusch, H. P., Expl. Cell Res., 66, 305 (1971).

    Article  CAS  Google Scholar 

  44. Matthews, H. R., J. Chromatog., 36, 302 (1968).

    Article  CAS  Google Scholar 

  45. Guttes, E., and Guttes, S., in Methods in Cell Physiology (edit. by Prescott, D. M.), 43 (Academic Press, New York, 1964).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bradbury, E., Inglis, R. & Matthews, H. Control of Cell Division by Very Lysine Rich Histone (F1) Phosphorylation. Nature 247, 257–261 (1974). https://doi.org/10.1038/247257a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/247257a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing