Abstract
WHEN the manic–depressive is psychologically disturbed, biogenic amine metabolism1, adrenal cortical activity2, the disposition of sodium3 and the concentration of cyclic AMP in the urine4 may be modified. During normothymic intervals none of these measures of endocrine function fall outside of normal limits1–4. Occasional and temporary diabetic-like responses to a glucose tolerance test appear, however, not only during episodes of depression and mania, but also during asymptomatic periods, despite an adequate carbohydrate intake and with no discernible impact on affect5. If, as we have suggested6, manic–depressives have a defect in the regulation of hormonal balance, an environmentally induced perturbation might make the difficulty apparent even when they are normothymic and their response to a glucose load is normal.
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GORDON, M., VAN DER VELDE, C. Metabolic Adaptation in the Manic–Depressive. Nature 247, 160–162 (1974). https://doi.org/10.1038/247160a0
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DOI: https://doi.org/10.1038/247160a0
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