Abstract
SEXUAL differentiation of gonadotrophin secretion in the rat is known to occur during the early postnatal period under the action of testicular androgens1,2. Animals of either sex if exposed to androgen during this critical period develop the typical male pattern of gonadotrophin secretion after puberty with failure of ovulation, small polyfollicular ovaries lacking corpora lutea and a constant cornified vaginal epithelium. Several studies have localised this effect to the brain3,4 and more particularly to the anterior hypothalamus5, but very little is yet known of the mechanism of this effect.
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SALAMAN, D., BIRKETT, S. Androgen-induced Sexual Differentiation of the Brain is Blocked by Inhibitors of DNA and RNA Synthesis. Nature 247, 109–112 (1974). https://doi.org/10.1038/247109a0
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DOI: https://doi.org/10.1038/247109a0
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