Abstract
WHEN antigen binding cells (ABC) were studied by combined autoradiography and immunofluorescence it was found that antigen binding to both B and T ABC could be inhibited by anti-immunoglobulin (anti-Ig) reagents1. Moreover, receptors for antigen could be redistributed in caps in a similar way for B and T ABC using non-inhibiting doses of anti-Ig reagents1. Since membrane components are known to redistribute independently of each other2–5 it was concluded from the inhibition and capping experiments that the receptor for antigen on T lymphocytes was immunoglobulin. The fact that T ABC are always a small minority of the total T cell population argues against the possibility that their receptors are passively acquired as cytophilic antibody. We present evidence confirming that T cells have receptors for antigen which are immunoglobulins and showing, in addition, that they are actively synthesised by the cells carrying them.
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References
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ROELANTS, G., RYDÉN, A., HÄGG, LB. et al. Active Synthesis of Immunoglobulin Receptors for Antigen by T Lymphocytes. Nature 247, 106–108 (1974). https://doi.org/10.1038/247106a0
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DOI: https://doi.org/10.1038/247106a0
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