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Differences in Murine Leukaemia Virus-specific DNA Sequences in Normal and Malignant Cells

Nature volume 246, pages 485–487 (1973)Cite this article

Abstract

IN many mouse strains, RNA tumour virus information is transmitted vertically (inherited) perhaps as part of the cell genome1,2. The activation of type C virus replication in cells from low leukaemia incidence mouse strains3 and from ‘virus-free’ cell lines4 by halogenated pyrimidines suggests that all mouse cells may contain murine leukaemia virus (MuLV) information, often in an unexpressed form. Indeed, proponents of the ‘oncogene’ hypothesis have predicted a complete copy of type C virus information in the genome of all somatic cells2.

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Author notes

  1. MICHAEL V. VIOLA

    Present address: Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, 99 Fort Washington Avenue, New York, New York, 10032

Authors and Affiliations

  1. Howard University School of Medicine, Washington DC, 20001

    MICHAEL V. VIOLA

  2. National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland, 20014

    LON R. WHITE

Authors
  1. MICHAEL V. VIOLA
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  2. LON R. WHITE
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VIOLA, M., WHITE, L. Differences in Murine Leukaemia Virus-specific DNA Sequences in Normal and Malignant Cells. Nature 246, 485–487 (1973). https://doi.org/10.1038/246485a0

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  • DOI: https://doi.org/10.1038/246485a0

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