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The Secretion of Migration Inhibitory Factor by Intact Schistosome Egg Granulomas maintained in vitro

Nature volume 246, pages 224–226 (1973)Cite this article

Abstract

TUBERCLE formation and delayed type dermal reactivity are the hallmarks of tuberculosis, yet the relationship between the two has only recently begun to be elucidated. Most experts still believe that the tuberculous granuloma is a tissue response to the irritative effect of mycobacterial lipids1,2. While the strength of this concept made it difficult to establish granulomatous inflammation as a host immunologic response3,5 Warren et al.6 showed that the schistosome egg granuloma is a manifestation of delayed hypersensitivity, as demonstrated by anamnestic reactivity, specificity, and transferability with immune lymphoid cells but not with antiserum. It was subsequently correlated with other parameters of the cell-mediated immune reaction, including delayed dermal reaction, lymphocyte transformation and macrophage-migration inhibition7. Similar results have been provided for the experimental tuberculous granuloma8–13. Here we report the secretion of a lymphokine by intact granulomas maintained in vitro, further confirming the hypersensitivity character of the schistosome egg granuloma.

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Authors and Affiliations

  1. Departments of Community Health and Medicine, Case Western Reserve University School of Medicine and University Hospital Cleveland, Ohio, 44106

    DOV L. BOROS, KENNETH S. WARREN & RONALD P. PELLEY

Authors
  1. DOV L. BOROS
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  2. KENNETH S. WARREN
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  3. RONALD P. PELLEY
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BOROS, D., WARREN, K. & PELLEY, R. The Secretion of Migration Inhibitory Factor by Intact Schistosome Egg Granulomas maintained in vitro. Nature 246, 224–226 (1973). https://doi.org/10.1038/246224a0

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