Abstract
OUR discovery that aspirin-like drugs inhibit the biosynthesis of prostaglandins1–3 led to the proposal that this was their main mechanism of action1,4. Several observations have added force to the theory. These include the correlation between relative potencies as prostaglandin synthetase inhibitors in vitro and anti-inflammatory activity in vivo5–7, the generality of the inhibition in many species and preparations8, and the demonstration of release of prostaglandins in inflammation9,10 and fever11,12. In addition, prostaglandins of the E series cause an inflammatory response in the skin of rats and man13,14 and a fever in cats15,16 and man17.
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MONCADA, S., FERREIRA, S. & VANE, J. Prostaglandins, Aspirin-like Drugs and the Oedema of Inflammation. Nature 246, 217–219 (1973). https://doi.org/10.1038/246217a0
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DOI: https://doi.org/10.1038/246217a0
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