Abstract
Use of a miniature pump to produce a local increase in velocity of medium across the surface of confluent 3T3 cells stimulates growth which is limited to the region of high velocity. This indicates that growth is limited by a diffusion boundary layer close to the cell surface. The events at the edge of wounded cell layers (topoinhibition) can be explained by local variation in the fluid microenvironment rather than by alterations in contact between cells.
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STOKER, M. Role of Diffusion Boundary Layer in Contact Inhibition of Growth. Nature 246, 200–203 (1973). https://doi.org/10.1038/246200a0
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DOI: https://doi.org/10.1038/246200a0
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