Abstract
The multiplication of epithelial cells in plastic dishes is limited by the amount of plastic surface available per cell, that of fibroblastic cells by the availability of medium factors. Contacts between cells do not appear to limit the multiplication of either cell type. The multiplication of fibroblastic cells is even favoured by shorter intercellular distances, suggesting a distance-dependent helper effect between cells.
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DULBECCO, R., ELKINGTON, J. Conditions Limiting Multiplication of Fibroblastic and Epithelial Cells in Dense Cultures. Nature 246, 197–199 (1973). https://doi.org/10.1038/246197a0
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DOI: https://doi.org/10.1038/246197a0
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