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Erythrocytes from Animals with Genetic Muscular Dystrophy

Nature volume 245, pages 156–157 (1973)Cite this article

Abstract

EFFECTS of congenital muscular dystrophy include changes in processes associated with membrane systems of muscle1,2. Moreover, there is evidence that genetic dystrophy in mice, which appears to be a suitable model for the human disease3, is associated with alteration of membrane events occurring in other tissue as well4–8. For example, we have reported altered proton permeability and related functions in liver mitochondria isolated from animals with the disease5. As aberrant membrane permeability could lead to the pathological state of muscle by producing defective excitation coupling, it is interesting to examine other tissues for evidence of systemic membrane dysfunction. We report here surface alterations of erythrocytes from dystrophic mice as revealed by scanning electron microscopy.

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References

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Authors and Affiliations

  1. Committee on Biochemistry and Department of Biology, Bowdoin College, Brunswick, Maine, 04011

    P. F. MORSE & J. L. HOWLAND

Authors
  1. P. F. MORSE
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  2. J. L. HOWLAND
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MORSE, P., HOWLAND, J. Erythrocytes from Animals with Genetic Muscular Dystrophy. Nature 245, 156–157 (1973). https://doi.org/10.1038/245156a0

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