Abstract
WHEN mammals are exposed to lead, the metal is incorporated into various tissues and also excreted in urine and bile. Lead is considered to pass into urine not only by glomerular filtration but also by direct transport through the tubular epithelial cells1. Histologically, tubular epithelial cells of lead poisoned kidney have been reported to have nuclear2 and extranuclear inclusions or concretions3,4, which are thought to contain lead. Biochemical examination of the kidney after administration of lead revealed that a considerable amount of lead was bound to mitochondrial and microsomal fractions5. Thus, the tubular epithelial cells of the kidney are understood not only to excrete lead into urine but also to deposit some to form inclusion bodies. The transportation of incorporated lead and the process of the formation of the inclusion body in the epithelial cells have, however, not yet been demonstrated.
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MURAKAMI, M., HIROSAWA, K. Electron Microscope Autoradiography of Kidney after Administration of 210Pb in Mice. Nature 245, 153–154 (1973). https://doi.org/10.1038/245153a0
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DOI: https://doi.org/10.1038/245153a0
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