Abstract
LUTEINIZING hormone–releasing hormone (LH–RH) is a decapeptide that has been identified in the hypothalamus of several species. Both the natural and synthetic peptides are active in stimulating the release of pituitary LH and follicle stimulating hormone (FSH) in many species including man1. We have developed a radioimmunoassay for this hormone capable of detecting as little as 20 pg LH–RH (ref. 2) and have attempted to apply it to the measurement of LH–RH in biological fluids.
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References
Schally, A. V., Arimura, A., Kastin, A. T., Matsuo, H., Baba, Y., Redding, T. W., Nair, R. M. G., Debeljuk, L., and White, R. A., Science, 144, 1344 (1971).
Jeffcoate, S. L., Fraser, H. M., Gunn, A., and Holland, D. T., J. Endocr., 57, 189 (1973).
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JEFFCOATE, S., HOLLAND, D., FRASER, H. et al. Identification by Radioimmunoassay of the Luteinizing Hormone–Releasing Hormone in Human Urine. Nature 244, 161–162 (1973). https://doi.org/10.1038/244161a0
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DOI: https://doi.org/10.1038/244161a0
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