Abstract
CYTOLOGICAL investigations indicate different possible origins of amniotic fluid cells (AFCs). The upper respiratory, gastrointestinal and genitourinary tracts, the skin, amnion and umbilical cord1,2 are all considered to be sources of AFC. The growth of epithelioid and fibroblastoid cells is common3 in the early stages of culture, and during further cultivation the cells are characterized by uniform fibroblastoid morphology, but their origin is not yet clear4,5. Our preliminary results in two human AFC lines suggest evidence of collagen synthesis in these cultures and include the examination of ratios of soluble to insoluble collagen6.
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MACEK, M., HURYCH, J. & ŘEZÁČOVÁ, D. Collagen Synthesis in Long-term Amniotic Fluid Cell Cultures. Nature 243, 289–290 (1973). https://doi.org/10.1038/243289a0
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DOI: https://doi.org/10.1038/243289a0
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