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Inhibition by Insulin of Cardiac Cathepsin D Activity

Nature volume 243, pages 226–227 (1973)Cite this article

Abstract

IN previous studies of foetal mouse hearts in organ culture, I have demonstrated that insulin improves net protein and amino acid balance1 and prolongs the duration of survival and beating in vitro2. The hormone exerts its action on amino acids such as phenylalanine whose metabolic pathways in the heart are confined almost exclusively to protein synthesis and degradation, as well as on those such as valine and alanine that may enter a variety of alternative pathways as well.

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Authors and Affiliations

  1. Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, Departments of Physiology and Internal Medicine, University of Texas Southwestern Medical School at Dallas, Dallas, Texas, 75235

    KERN WILDENTHAL

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  1. KERN WILDENTHAL
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WILDENTHAL, K. Inhibition by Insulin of Cardiac Cathepsin D Activity. Nature 243, 226–227 (1973). https://doi.org/10.1038/243226a0

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