Abstract
ALTHOUGH it is known that intestinal calcium malabsorption may occur in chronic alcoholic patients indirectly as a result of steatorrhoea of multiple causes1–7, producing inadequate absorption of fat-soluble vitamin D, little attention has been paid to possible direct effect on small intestinal transport. To test that possibility, I starved male albino rats 8 h before and 18 h after the acute administration of ethanol (7.5 g kg−1 body weight) or isocaloric glucose (13.7 g kg−1; they were, however, permitted free access to water. Chronic ethanol ingestion was achieved by giving 20% ethanol in water as a sole source of fluid and standard laboratory chow was fed ad libitum for 12 d. Comparisons were made with ad libitum and pair-fed controls. Calcium transport by duodenum and ileum was measured using an in vitro everted gut sac technique8.
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KRAWITT, E. Ethanol inhibits Intestinal Calcium Transport in Rats. Nature 243, 88–89 (1973). https://doi.org/10.1038/243088a0
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DOI: https://doi.org/10.1038/243088a0
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