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Toxicology of Fluoro-olefins

Abstract

THE often surprising toxicity of several of the fluorinated organic compounds is well known1. A number of rather diverse structural types have been found to impart high toxicity although seemingly closely related types have been found to have rather low toxicities. Unfortunately, this varied behaviour of fluorinated compounds has occasionally become tragically established. While the modus operandi is now known for types such as monofluorides2, phosphofluoridates3, and active halogen compounds, for example, α-haloketones, much less is understood about fluorinated alkenes4.

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References

  1. van Oettingen, W. F., The Halogenated Aliphatic, Olefinic, Cyclic, Aromatic, and Aliphatic-Aromatic Hydrocarbons, including the Halogenated Insecticides, Their Toxicity and Potential Dangers (US Public Health Service, 1955).

    Google Scholar 

  2. Pattison, F. L. M., and Peters, R. A., in Handbuch der Experimentellen Pharmakologie (edit. by Eichler O., Farah, A., Herken, H., and Welch, A. D.), 20, 1, Pharmacology of Fluorides (edit. by Smith, F. A), 387 (Springer, New York, 1966).

    Google Scholar 

  3. O'Brien, R. D., Toxic Phosphorus Esters (Academic Press, New York, 1960).

    Google Scholar 

  4. Clayton, jun., J. W., in Handbuch der Experimentellen Pharmakologie (edit. by Eichler, O., Farah, A., Herken, H., and Welch, A. D.), 20, 1, Pharmacology of Fluorides (edit. by Smith, F. A.), 459 (Springer, New York, 1966).

    Google Scholar 

  5. Raventos, J., and Lemon, P. G., Brit. J. Anesthesia, 37, 716 (1965).

    Article  CAS  Google Scholar 

  6. Park, J. D., McMurtry, R. J., and Adams, J. H., Fluorine Chem. Rev., 2, 55 (1968).

    Google Scholar 

  7. Park, J. D., and Cook, E. W., Tetrahedron Lett., 4853 (1965).

  8. Biological Effects of Alkylating Agents (edit. by van Duuren, B. L.), Ann. NY Acad. Sci., 163, Art. 2 (1969).

  9. Clayton, jun., J. W., Fluorine Chem. Rev., 1, 197 (1967).

    CAS  Google Scholar 

  10. Sheppard, W. A., and Sharts, C. M., Organic Fluorine Chemistry (Benjamin, New York, 1969).

    Google Scholar 

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COOK, E., PIERCE, J. Toxicology of Fluoro-olefins. Nature 242, 337–338 (1973). https://doi.org/10.1038/242337a0

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