Abstract
PREHN has advanced the hypothesis that weakly antigenic tumours can lead to a cell-mediated response which stimulates, rather than inhibits, tumour growth1–3. His hypothesis was based on evidence which indicated that a low level immune reaction might enhance tumour growth. Much of this evidence came from experiments using mouse mammary tumours1,2, although the presence of enhancing or blocking antibodies could explain many of the data4,5. Prehn's demonstration that low doses, but not high doses, of specifically sensitized spleen cells could benefit tumour growth in thymectomized, X-irradiated mice provided the first substantial evidence for the immunostimulation theory3.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Prehn, R. T., J. Reticuloendothel. Soc., 10, 1 (1971).
Prehn, R. T., Science, 176, 170 (1972).
Prehn, R. T., and Lappe, M. A., Transplant. Rev. (in the press).
Heppner, G. H., Int. J. Cancer, 9, 119 (1972).
Hellström, I., and Hellström, K. E., in In Vitro Methods in Cell-Mediated Immunity (edited by Bloom, B.R., and Glade, P. R.), 409 (Academic Press, New York, 1971).
Medina, D., and DeOme, K. B., J. Nat. Cancer Inst., 40, 1303 (1968).
Medina, D., and DeOme, K. B., J. Nat. Cancer Inst., 45, 353 (1970).
Medina, D., Methods in Cancer Research, 7, 1 (1973).
Weiss, D. W., Sulitzeanu, A., Young, L., Adelberg, M., and Segev, Y., Is. J. Med. Sciences, 7, 187 (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MEDINA, D., HEPPNER, G. Cell-mediated “Immunostimulation” induced by Mammary Tumour Virus-free Balb/c Mammary Tumours. Nature 242, 329–330 (1973). https://doi.org/10.1038/242329a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/242329a0
This article is cited by
-
Lymphatic invasion and metastasis
Experientia (1977)
-
The role of the immune response in oncogenesis
In Vitro (1975)
-
Analyse der virusinduzierten Transplantationsimmunit�t gegen SV40-Tumoren: Die Bedeutung humoraler Antik�rper und des SV40-spezifischen Oberfl�chenantigens
Zeitschrift f�r Krebsforschung und Klinische Onkologie (1974)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
