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Frequent expression of HAGE in presentation chronic myeloid leukaemias

Leukemia volume 16, pages 2238–2242 (2002)Cite this article

Abstract

Cancer testis (CT) antigens provide attractive targets for cancer-specific immunotherapy. Although CT genes are expressed in some normal tissues, such as the testis and in some cases placenta, these immunologically protected sites lack MHC I expression and as such, do not present ‘self’ antigens to T cells. To date, CT genes have been shown to be expressed in a range of solid tumours, but rarely in haematological malignancies. We have extended previous studies to investigate the expression of a comprehensive range of CT genes (MAGE-A1, -A3, -A6, -A12, BAGE, GAGE, HAGE,LAGE-1, NY-ESO-1 and RAGE) for their expression in a cohort of acute and chronic myeloid leukaemia patient samples. CT expression was not detected in 20 normal bone marrow or peripheral blood stem cell samples. In acute myeloid leukaemia (AML) nine of the 26 (35%) samples analysed expressed one or more of the CT genes with six of the samples (23%) expressing HAGE. In chronic myeloid leukaemia (CML) 24 of 42 (57%) presentation chronic myeloid leukaemia (CML) patient samples expressed one or more CT antigen with 23 expressing HAGE. We have shown that HAGE is frequently expressed in CML, and to a lesser extent in AML patient samples. This is the first demonstration of HAGE gene expression in myeloid leukaemia patients and the frequent expression of HAGE at disease presentation opens up the possibility of early immunotherapeutic treatments.

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Acknowledgements

We would like to thank Ms Guillermina Nickless and Mr Stephen Orr for technical assistance. SSS and BG are funded by the Leukaemia Research Fund.

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Authors and Affiliations

  1. Department of Haematological Medicine, Leukaemia Science Laboratories, Guy's, King's & St Thomas’ School of Medicine, Rayne Institute, London, UK

    SP Adams, A Mijovic, B Czepulkowski, RA Padua, GJ Mufti & BA Guinn

  2. Molecular Immunology Group, Tenovus Laboratory, Southampton University Hospital, Southampton, UK

    SS Sahota

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  1. SP Adams
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  2. SS Sahota
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  3. A Mijovic
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  4. B Czepulkowski
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  5. RA Padua
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  7. BA Guinn
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Adams, S., Sahota, S., Mijovic, A. et al. Frequent expression of HAGE in presentation chronic myeloid leukaemias. Leukemia 16, 2238–2242 (2002). https://doi.org/10.1038/sj.leu.2402732

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