Abstract
THE nature of the scrapie agent1,2 is of considerable interest especially as to whether it is a virus in the strict sense, or some replicating agent devoid of nucleic acid3,4, or indeed whether scrapie disease represents a transmissible progressive biochemical transformation of cellular membranes5,6. Thorough electron microscope studies have been carried out in the disease and, although a number of particles have (not unexpectedly) been described7,8, their role in scrapie is unconfirmed, especially as none has the special features associated with virions or has the size or other characters currently attributed to the agent.
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NARANG, H., SHENTON, B., GIORGI, P. et al. Scrapie Agent and Neurones. Nature 240, 106–107 (1972). https://doi.org/10.1038/240106a0
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DOI: https://doi.org/10.1038/240106a0
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