Abstract
The t(14;18) is the most frequent chromosomal aberration observed in follicular non-Hodgkin’s lymphoma (NHL), and less frequently in diffuse large cell lymphoma (DLCL). The t(14;18) does not affect overall survival in follicular NHL or DLCL. It provides a unique lymphoma-specific marker that can be used to quantify residual disease during treatment, and may forward evaluation of new treatment protocols. The t(14;18) results in the deregulation of bcl-2, a proto-oncogene that protects against induction of programmed cell death (PCD). Nowadays, a whole family of bcl-2-related genes has been identified and consist of members which can either protect or promote induction of PCD. The family members form protein dimers, and the relative abundance of specific dimers regulates the cellular sensitivity to death signals (the rheostat model). Aberrant expression of different family members in several types of malignancies alter the cellular rheostat and thereby promote cellular resistance to chemotherapy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meijerink, J. t(14;18), a journey to eternity. Leukemia 11, 2175–2187 (1997). https://doi.org/10.1038/sj.leu.2400849
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2400849
Keywords
This article is cited by
-
Meat intake and risk of non-Hodgkin lymphoma
Cancer Causes & Control (2012)
-
Cytogenetic biomonitoring of inhabitants of a large uranium mineralization area: the municipalities of Monte Alegre, Prainha, and Alenquer, in the State of Pará, Brazil
Cell Biology and Toxicology (2010)
-
Follicular lymphoma without t(14;18) and with BCL-6 rearrangement: a lymphoma subtype with distinct pathological, molecular and clinical characteristics
Leukemia (2002)
-
Relationship between expression of genes involved in cell cycle control and apoptosis in diffuse large B cell lymphoma: a preferential survivin–cyclin B link
Leukemia (2002)
-
Suppression of apoptosis: role in cell growth and neoplasia
Leukemia (2001)