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Monoclonal antibodies specific for P-glycoprotein

Leukemia volume 11, pages 1119–1123 (1997)Cite this article

Abstract

Multidrug resistance (MDR) is one of the major obstacles to successful cancer chemotherapy. Since P-glycoprotein (P-gp) encoded by the MDR-1 gene plays a key role in MDR, many P-gp-specific monoclonal antibodies (MAbs) have been generated for characterization and analysis of P-gp. Among those antibodies, MRK16 has been widely used not only for elucidation of the mechanisms of P-gp-mediated MDR but also for diagnostic and therapeutic studies. Two types of magnetic cell sorting assays, termed MRK16-MACS and MRK16-MACS-FACS, have been established by us and may offer a useful tool to quantitate low levels of P-gp expression. This article describes the characteristics of the antibodies against P-gp and discuss the diagnostic implications of the antibodies.

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Authors and Affiliations

  1. Nippon Hoechst Marion Roussel, Kawagoe, Saitama, Japan

    E Okochi & T Iwahashi

  2. Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan

    T Tsuruo

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  1. E Okochi
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  2. T Iwahashi
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  3. T Tsuruo
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Okochi, E., Iwahashi, T. & Tsuruo, T. Monoclonal antibodies specific for P-glycoprotein. Leukemia 11, 1119–1123 (1997). https://doi.org/10.1038/sj.leu.2400658

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  • DOI: https://doi.org/10.1038/sj.leu.2400658

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