Abstract
Increase of stillbirths and adverse maternal effects in rats after administration of aspirin and indomethacin in the final days of pregnancy warns against their use in the late stages of human pregnancy.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Karim, S. M. M., Brit. Med. J., 4, 618 (1968).
Karim, S. M. M., and Devlin, J., J. Obstet. Gynaecol. Brit. Commonw., 74, 230 (1967).
Karim, S. M. M., Trussel, R. R., Hellier, K., and Patel, R. C., J. Obstet. Gynaecol. Brit. Commonw., 76, 769 (1969).
Karim, S. M. M., Hellier, K., Trussel, R. R., Patel, R. C., and Tamusange, S., J. Obstet. Gynaecol. Brit. Commonw., 77, 200 (1970).
Karim, S. M. M., and Filshie, G. M., Lancet, i, 157 (1970).
Roth-Brandel, U., Bygdeman, M., Wiquist, N., and Bergström, S., Lancet, i, 190 (1970).
Piper, P., and Vane, J. R., Ann. NY Acad. Sci., 180, 363 (1971).
Horton, E. W., Jones, R., Thompson, C., and Poyser, N., Ann. NY Acad. Sci., 180, 351 (1971).
Vane, J. R., Nature, 231, 232 (1971).
Smith, J. B., and Willis, A. L., Nature, 231, 235 (1971).
Ferreira, S. H., Moncada, S., and Vane, J. R., Nature, 231, 237 (1971).
Tomlinson, R. V., Ringold, J. H., Qureshi, M. C., and Forchielli, E., Biochem. Biophys. Res. Commun., 45, 552 (1972).
Stutzman, J. W., Orth, O. S., and Mellish, C. H., J. Pharmacol. Exp. Ther., 73, 420 (1941).
Hart, E. R., J. Pharmacol. Exp. Ther., 89, 205 (1947).
Vane, J. R., and Williams, K. I., Brit. J. Pharmacol., 45, 146P (1972).
Tothill, A., Brit. J. Pharmacol., 29, 291 (1967).
Tothill, A., Rathbone, L., and Willman, E., Nature, 233, 56 (1971).
Nickander, R. C., Kraay, R. J., and Marshall, W. S., Fed. Proc., 30, 563A (1971).
Karim, S. M. M., J. Pharm. Pharmacol., 18, 519 (1966).
Collier, J. G., and Flower, R. J., Lancet, i, 852 (1971).
Ramwell, P., and Shaw, J., Ann. NY Acad. Sci., 180, 101 (1971).
Vane, J. R., Brit. J. Pharmacol. Chemother., 12, 344 (1957).
Regoli, D., and Vane, J. R., Brit. J. Pharmacol. Chemother., 23, 351 (1964).
Mann, M., and West, G. B., Brit. J. Pharmacol. Chemother., 5, 173 (1950).
Gaddum, J. H., Brit. J. Pharmacol. Chemother., 8, 292 (1953).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
AIKEN, J. Aspirin and Indomethacin Prolong Parturition in Rats: Evidence that Prostaglandins Contribute to Expulsion of Foetus. Nature 240, 21–25 (1972). https://doi.org/10.1038/240021a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/240021a0
This article is cited by
-
Animal models of postpartum hemorrhage
Lab Animal (2024)
-
Hormonal and local regulation of uterine activity during parturition: part II — The prostaglandin and adrenergic systems
Journal of Endocrinological Investigation (1994)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.