Abstract
THE release of histamine and other mediators of immediate type anaphylactic reactions from mast cells is triggered by the interaction of antigen with cell-bound antibody. Antigen-induced histamine release and that induced by Compound 48/80 are energy-dependent processes which are depressed by metabolic inhibitors and follow a similar time course1–3. This type of selective release of histamine is inhibited by the potent anti-asthmatic drug disodium cromoglycate (DSCG)4, whereas the non-selective release induced by agents such as the detergent ‘Triton X-100’, which follows a different time course and is not energy dependent, is not blocked by DSCG. It has therefore been postulated4,5 that histamine is released from mast cells by two distinct mechanisms: a selective release of amine-containing granules through a process of exocytosis, and a non-selective release of amines and other cellular constituents as a result of lysis of cell membranes.
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ORR, T., HALL, D. & ALLISON, A. Role of Contractile Microfilaments in the Release of Histamine from Mast Cells. Nature 236, 350–351 (1972). https://doi.org/10.1038/236350a0
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DOI: https://doi.org/10.1038/236350a0
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