Abstract
THE catecholamine hypothesis of affective disorders1,2, which associates decreased functional catecholamines with depression, has been tested by measurement of noradrenaline (NA) in plasma or urine or the NA metabolites, normetanephrine and VMA in urine3–5. Probably only a small percentage of these compounds originate from the central nervous system6, and so it is not surprising that this has led to conflicting results.
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WILK, S., SHOPSIN, B., GERSHON, S. et al. Cerebrospinal Fluid Levels of MHPG in Affective Disorders. Nature 235, 440–441 (1972). https://doi.org/10.1038/235440a0
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DOI: https://doi.org/10.1038/235440a0
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